WPBO, virtual channel 42 (UHF digital channel 43) is a Telemundo-affiliated television station that serves extreme southern Ohio and the western edge of the Huntington–Charleston, West Virginia market area from a transmitter near West Portsmouth. It is owned by the News-Press & Gazette Company. Until October 2017, WPBO served as a full-time satellite of PBS member station WOSU-TV, based in Columbus, Ohio.

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